A One Year Retrospective Review of Intrauterine Insemination at the Center for Fertility and Reproductive Medicine of Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
Date
2020-09-01Metadata
Show full item recordAbstract
Conclusions: As the pregnancy rate found in this study was comparable with other studies and due to its affordability, IUI remains an effective first line method among the available options for infertile couples, especially for those with unexplained sub fertility. Further prospective studies with larger sample sizes may be necessary to confirm the results of this study.
Background: Intrauterine insemination (IUI) with ovarian stimulation is a procedure used for treating couples with unexplained subfertility, mild endometriosis, ovulatory dysfunction, mild male factor subfertility and cervical factor infertility. Even though it is one year it was started to be practice in Saint Paul’s hospital there is no study done in the country to see success rate, common indications and associated factors.
Objective: The aim of this study is to describe the socio demographic characteristics, clinical characteristics, indications, success rate and potential factors associated with success rate of couples undergoing IUI.
Material and Methods: Records of all couples who underwent IUI at center for fertility and reproductive medicine (CFRM) of Saint Paul’s Hospital Millennium Medical College (SPHMMC), from May 1, 2019 to April 30, 2020 were reviewed. A total of 139 IUI cycles on 117 couples were done as documented in the Laboratory record. Out of these a retrospective, descriptive analysis of 97 couples (111 cycles) documents were found to be complete enough to be included in the review. Twenty couples (28 cycles) were excluded due to unknown pregnancy test status and loss of their chart. The socio demographic characteristics, type of infertility, duration of infertility, cause of infertility, ovulation induction agent, dose of trigger, sperm characteristics, method of sperm preparation, and baseline laboratory results of the couples were documented using data extraction format. Pregnancy success rate was determined based on urine HCG result after two weeks of the procedure. Logistic regression of variables with 90% confidence interval and Ki -square test was done to see association between success rate of pregnancy and predictive variables.
Results: The mean age of women was 32.04± 4.61years while the mean age of partner was 37.36± 6.71years. The couples were infertile for 5.23±3.24 (mean ±SD) years. Most of the couples, 66(68.04%), have primary infertility and the most common cause of infertility was unexplained subfertility 69(71.13%). The pregnancy rate was 9.0% per cycle and 10.31% per couple. None of the predictor variable show statistically significant association with success rate of pregnancy.Conclusions: As the pregnancy rate found in this study was comparable with other studies and due to its affordability, IUI remains an effective first line method among the available options for infertile couples, especially for those with unexplained sub fertility. Further prospective studies with larger sample sizes may be necessary to confirm the results of this study.