Follow up and Treatment Outcome of Gestational Trophoblastic Disease Patients Admitted to St. Paul’s Hospital Millennium Medical College

Abstract

<p><strong>Background: </strong>Gestational&nbsp;&nbsp; trophoblastic disease (GTD) is the term used to describe the heterogeneous group of interrelated lesions that arise from abnormal proliferation of placental trophoblasts. There is higher incidence in women of Far Eastern origin and African than&nbsp; for&nbsp; white&nbsp; women&nbsp; from&nbsp; the&nbsp; United&nbsp; Kingdom&nbsp; and&nbsp; other&nbsp; Western&nbsp; countries. The reasons for this are not clear but might reflect low socioeconomic status and diet deficient in protein, folic acid and carotene. Improvement in management and follow up protocols means that overall cure rates can exceed 98% with fertility retention.</p> <p><strong>Objectives</strong><strong>: </strong>The objective of this study was to review the follow up and treatment outcome of GTD patients managed in Saint Paul’s hospital millennium medical college.</p> <p><strong>Methodology: </strong>A cross-sectional retrospective analysis was done on all cases of GTD patients managed at Saint Paul’s Hospital Millennium Medical College, for three years, from January 2013 to December 2015. Data was collected using pretested questionnaires from patient file. P-value set at 0.05 and 95% confidence interval was used to determine the statistical significance of the associations.</p> <p><strong>Results and conclusion: </strong>The magnitude of GTD was 6.3/1000 deliveries in SPHMMC during the study period. The Diagnosis of GTN was made in 28(22.4%) of the cases and age &gt;35 was associated with the development of GTN. About 74(59.2%) had one or more post molar follow up of which only 50(40.0%) followed till they achieve remission. Residence in Addis Ababa was associated with post molar follow up. The final disease outcome was not known in majority of the patients 61(48.8%).</p>